Point Spread: The point spread remains the favorite way to wager on pro football, regardless of how many new forms of wagering come on stream. ItÂ's called. Seattle Seahawks vs San Francisco 49ers Odds - Sunday January 1 Live betting odds and lines, betting trends, against the spread and. San Francisco 49ers ' spreads for Weeks Saul Loeb/AFP/Getty Cantor Technology released the spreads for every NFL game in Weeks Below are the lines Seahawks at 49ers (+). Week 49ers (+4).